Plcz1 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comPlcz1 Polyclonal Antibody for Mouse(Mus musculus)

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Plcz1 (Gene name),

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 (Protein name ), PLCZ1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Plcz1;

Protein name:

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1;

Alternative:

Phospholipase C-zeta-1(PLC-zeta-1);Phosphoinositide phospholipase C-zeta-1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.

Function:

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.

Subcellular Location:

Nucleus Cytoplasm perinuclear region Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronuclei at interphase following meiosis and mitosis.

Protein Attributes:

Sequence length:

647

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

647:

SGNELLGQYT | LPVLCMNKGY | RRVPLFSKSG | ANLEPSSLFI | YVWYFRE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8K4D7

UniGene:

Mm.50808

KEGG:

mmu:114875

Pfam:

PF00168

SMR:

Q8K4D7

Uniprot:

Q8K4D7

FOR

ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

E15484h

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MSDS:

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Packing:

96T

ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

E15484c

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MSDS:

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Packing:

96T

ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

E15484m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

E15484r

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Packing:

96T

ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

E15484b

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Packing:

96T

CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

U15484m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

U15484h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

U15484r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

U15484c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

U15484b

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

P15484Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

P15484Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Cat.:

P15484Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

Protein for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development."
Saunders C.M. , Larman M.G. , Parrington J. , Cox L.J. , Royse J. , Blayney L.M. , Swann K. , Lai F.A.
Development129:3533-3544(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
strain: C57BL/6J.
tissue: Spermatid.
2.

"Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs."
Kouchi Z. , Fukami K. , Shikano T. , Oda S. , Nakamura Y. , Takenawa T. , Miyazaki S.
J. Biol. Chem.279:10408-10412(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;SUBCELLULAR LOCATION
tissue: Testis.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Testis.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"Mammalian phospholipase Czeta induces oocyte activation from the sperm perinuclear matrix."
Fujimoto S. , Yoshida N. , Fukui T. , Amanai M. , Isobe T. , Itagaki C. , Izumi T. , Perry A.C.F.
Dev. Biol.274:370-383(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
6.

"Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta."
Larman M.G. , Saunders C.M. , Carroll J. , Lai F.A. , Swann K.
J. Cell Sci.117:2513-2521(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-377
7.

"Nuclear translocation of phospholipase C-zeta, an egg-activating factor, during early embryonic development."
Sone Y. , Ito M. , Shirakawa H. , Shikano T. , Takeuchi H. , Kinoshita K. , Miyazaki S.
Biochem. Biophys. Res. Commun.330:690-694(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
8.

"The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta."
Kouchi Z. , Shikano T. , Nakamura Y. , Shirakawa H. , Fukami K. , Miyazaki S.
J. Biol. Chem.280:21015-21021(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;COFACTOR;INTERACTION WITH PTDINS(3)P AND PTDINS(5)P;DOMAIN
9.

"Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations."
Nomikos M. , Blayney L.M. , Larman M.G. , Campbell K. , Rossbach A. , Saunders C.M. , Swann K. , Lai F.A.
J. Biol. Chem.280:31011-31018(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN
10.

"The role of X/Y linker region and N-terminal EF-hand domain in nuclear translocation and Ca2+ oscillation-inducing activities of phospholipase Czeta, a mammalian egg-activating factor."
Kuroda K. , Ito M. , Shikano T. , Awaji T. , Yoda A. , Takeuchi H. , Kinoshita K. , Miyazaki S.
J. Biol. Chem.281:27794-27805(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN;MUTAGENESIS OF ASP-210; LYS-299; LYS-301; ARG-376; LYS-377; ARG-378; LYS-379 AND LYS-381
11.

"Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice."
Yoshida N. , Amanai M. , Fukui T. , Kajikawa E. , Brahmajosyula M. , Iwahori A. , Nakano Y. , Shoji S. , Diebold J. , Hessel H. , Huss R. , Perry A.C.
Development134:3941-3952(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;OVEREXPRESSION
12.

"Proteolytic processing of phospholipase Czeta and [Ca2+]i oscillations during mammalian fertilization."
Kurokawa M. , Yoon S.Y. , Alfandari D. , Fukami K. , Sato K. , Fissore R.A.
Dev. Biol.312:407-418(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN
13.

"Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish."
Ito M. , Shikano T. , Oda S. , Horiguchi T. , Tanimoto S. , Awaji T. , Mitani H. , Miyazaki S.
Biol. Reprod.78:1081-1090(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION

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